Ascertainment Bias in Family-based Case-Control Studies
نویسندگان
چکیده
منابع مشابه
Adjusting for bias due to incomplete case ascertainment in case-control studies of birth defects.
Case-control studies of birth defects might be subject to selection bias when there is incomplete ascertainment of cases among pregnancies that are terminated after a prenatal diagnosis of the defect. We propose a simple method to estimate inverse probability of selection weights (IPSWs) for cases ascertained from both pregnancies that end in termination and those that do not end in termination...
متن کاملFamily-Based Case–Control Studies
Case–control studies are used often in epidemiologic studies to investigate the association between disease and one or more risk factors. With increasing frequency, the set of risk factors being considered includes genotypes at one or more susceptibility, candidate, or marker loci (see Markers). The goals of association studies will differ, depending on the state of knowledge about a given dise...
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Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider famil...
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When some individuals are screen-detected before the beginning of the study, but otherwise would have been diagnosed symptomatically during the study, this results in different case-ascertainment probabilities among screened and unscreened participants, referred to here as lead-time-biased case-ascertainment (LTBCA). In fact, this issue can arise even in risk-factor studies nested within a rand...
متن کاملAscertainment bias in studies of human genome-wide polymorphism.
Large-scale SNP genotyping studies rely on an initial assessment of nucleotide variation to identify sites in the DNA sequence that harbor variation among individuals. This "SNP discovery" sample may be quite variable in size and composition, and it has been well established that properties of the SNPs that are found are influenced by the discovery sampling effort. The International HapMap proj...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2002
ISSN: 0002-9262
DOI: 10.1093/aje/155.9.875